A review of current bioanalytical approaches in sample pretreatment techniques for the determination of antidepressants in biological specimens

Abstract Antidepressants are a class of compounds widely used in clinical settings for the treatment several diseases. In last years there has been considerable increase their consumption, representing an important public health issue countries. Because they substances with narrow therapeutic windows, and since capable interacting other classes compounds, monitoring these is relevance, minimizing risk medical interactions as well side toxic effects. addition, understanding extent use, detection through routine toxicology tests development new methods extreme importance concerning health, patient well-being, implications forensic situations. The main objective this work to perform critical review on biological samples quantification antidepressants special focus techniques sample preparation.